Assay for Early Diagnosis of Anthrax Using Monoclonal Antibodies Against...
Anthrax is a serious infectious disease caused by bacteria known as Bacillus anthracis. Anthrax-contaminated spores can be found naturally in soil and they commonly affect domestic and wild animals...
View ArticleReal-time PCR Detection of Streptococcus pneumoniae with High Sensitivity and...
Streptococcus pneumoniae is the leading cause of community-acquired pneumonia and is also a frequent cause of bloodstream, brain and spinal cord, ear, and sinus infections. According to 2015 CDC data,...
View ArticleChimeric Reporter West Nile/Dengue Viruses and Their Use for Assay Development
CDC researchers have engineered West Nile/dengue virus (WN/DENV) chimeras utilizing the replicative ability of the West Nile (WN) virus but presenting the immunogenic pre-membrane and envelope surface...
View ArticleDiagnostic Assay with Modified Cardiolipin for Detecting Active Syphilis...
Syphilis is a sexually transmitted infection that remains a global health threat. The World Health Organization estimates that more than 12 million new cases are reported in adults annually worldwide....
View ArticleHigh-throughput assay for detection of rabies neutralizing antibodies
According to 2010-2014 World Health Organization (WHO) research, dog-transmitted human rabies was present or suspected in 150 countries and territories worldwide. Domestic dogs were the most common...
View ArticleMonoclonal Antibody to Detect the Antiretroviral Drug Emtricitabine – for HIV...
The U.S. Food and Drug Administration and World Health Organization (WHO) approved the antiretroviral drug emtricitabine (FTC)/ tenofovir disoproxil fumurate (TDF) combination for HIV pre-exposure...
View ArticleOne-step random amplification method to detect extremely low input nucleic...
Clinical and biological specimens often contain microbial nucleic acid in extremely low quantities, presenting a significant challenge for the detection of viral and bacterial pathogens. This also...
View ArticleHandwipe Disclosing Method for Detecting the Presence of Lead
Lead (Pb) exposure can cause serious health concerns including abdominal pain, headaches, loss of appetite, memory loss, weakness, and other symptoms. Lead residues on human skin, especially on the...
View ArticlePhotoinduced Electron Transfer Fluorescent Primer for Nucleic Acid Amplification
CDC scientists have developed a rapid and cost-efficient method for generating fluorescently labeled primers for PCR and real-time PCR. At present, fluorescent primers are useful for detecting and...
View ArticleMonitoring Public Water Supply for a Variety of Pathogens
The simultaneous concentration and recovery of microbes in drinking water is important for responding to potential water-related events such as pathogen contamination or bioterrorism and could be a...
View ArticleReal-Time RT-PCR Detection of Rickettsia species -- PanR6/Total Nucleic Acid...
Rickettsial infections are caused by bacteria from the Rickettsia genus which are often spread by biting ticks, fleas, mites or lice. Rickettsia can cause mild to severe illness and Rickettsia species...
View ArticleSimian T-Cell Lymphotropic Virus Strain Type 3 (STLV-3) Subtype D Variant, a...
Simian T-cell lymphotropic viruses (STLV) are nonhuman primate retroviruses closely related to the human T-lymphotropic virus (HTLV). Types I, II, and III of HTLV have been found in humans and are...
View ArticleStable Human Cell Lines Expressing Flavivirus Virus-Like Particles (VLPs) for...
Flaviviruses such as Zika virus, dengue virus, West Nile virus, yellow fever virus, and Japanese encephalitis virus cause widespread illness and death throughout the world. Typically, flaviviruses get...
View ArticleMonoclonal Antibodies Against Coxiella burnetii, the Cause of Q Fever for...
Coxiella burnetii (C. burnetii), the bacterium that causes Q fever, gets transmitted by inhalation and remains extremely stable in the environment. It has a very low infectious dose (very few bacteria...
View ArticleMonoclonal Antibodies for Detection of Rabies Virus Antigen and Confirmatory...
According to the World Health Organization (WHO), rabies causes greater than 59,000 deaths every year in over 150 countries as of 2017. A rapid and reliable diagnostic test for rabies is critical for...
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